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Copper Amino Isolate Serum: The Second Generation

CAIS2 is the second generation of NIOD’s multi-award-winning Copper Amino Isolate Serum.

As a highly-focused effort to maintain healthy-looking skin, this pro-repair, pro-collagen serum offers a novel approach to target all signs of skin aging indirectly. This indirect approach departs from the traditional thinking of addressing visible aspects of skin aging individually and instead forms a foundation to respect overall skin health. 

The science behind this product is patent pending and has resulted in a product that doesn’t only repair damage but proactively works to improve overall quality of skin across a spectrum of issues that crop up with age including pore enlargement, loss of elasticity, dullness, inflammation, uneven skin tone etc. One of the best things about DECIEM is that they are constantly adapting formulas to make them the best. One big change they have made is with the formulation of this product. The serum comes in two bottles and when it first launched, one bottle contained 100% pure powdered Copper Tripeptide-1 and the other was the liquid “activator” containing the other ingredients. Now, the CP-1 comes in a pre-stabilized liquid form. The original formula had to be refrigerated to keep it stable and active, but that’s not necessary anymore. This is a really important change as it makes the serum a lot more travel friendly and much easier to mix and store.

So how does CAIS actually work? 

CAIS2 supplies 2% pure GHK peptide (Tripeptide-1) separate from copper ions. Upon mixing, 1% Copper Tripeptide-1 (GHK-Cu) is freshly formed as 1% of the GHK peptide branches with free copper ions, leaving 1% pure GHK in free form. Both GHK and GHK-Cu are found in nature and originally isolated from human plasma. The concentration of these peptides in human plasma continues to drop with ageing past late teenage years and this drop exceeds 60% by the age of 60. The natural role of peptides as found in the human body includes activation of a wide range of skin health functions, including healing, immune function, collagen synthesis, fibroblast production and anti-inflammatory responses, while pure GHK offers strong pro-collagen support. 

How do I use NIOD's Copper Amino Isolate Serum?

You apply it immediately after cleansing, straight on to bare skin and you shouldn’t need a lot (I use about 4-5 drops) as the texture is light and watery. I like to spread the serum between my palms and then press it in to the skin. You can also use more to spot treat troublesome areas as well as use it around the eyes before applying your usual serum or cream. This serum takes less than 30 seconds to absorb, but make sure you wait that amount of time before moving on to your next step (especially if you’re using an acid) to ensure that whatever you apply on top doesn’t interfere with CAIS. It sinks in quickly, leaving the skin dry to the touch with no residue.

What does NIOD CAIS do and how does it work?

This high 2% concentration of GHK and GHK-Cu in CAIS2 is not available in other topical creams and targets signs of skin aging, including visible textural damage, uneven tone, visibly enlarged pores, and a general lack of healthy radiance normally present in younger skin. In short, skin will look healthier with continued visible improvements with continued use. 

Other than this, the presence of more than 9.0% Pure Undiluted Tripeptide-29, an amino acid sequence of Glycine-Proline-Hydroxyproline supports healthy collagen and works synergistically with GHK and GHK-Cu in this function. It also contains more than 4.0% complex of Acetyl Tetrapeptide-2 and Trifluroacetyl Tripeptide-2, which are advanced peptide technologies that support healthy collagen quality and assembly for skin that looks firmer and more evenly modeled.

This product is also plant based since the 0.10% glycogen is 100% pure plant-based mono-dispersed and acts like hard spheres that protect the formulation peptides but break upon application for optimal dermal exposure. It also contains more than 9% complex of Myristoyl Nonapeptid-3, a lipo-oligopeptide that supports healthy skin renewal which is essential for penetration of technologies in this formulation and those used in any subsequent treatments. It also contains Hyaluronic Acid Crosspolymer, a unique cross-linked non-animal form, which helps with delivery of water and water-soluble actives through its non-equilibrium gel structure. 


NIOD Copper Amino Isolate Serum 1.00% Ingredients: 

  • COPPER CONCENTRATE: Aqua (Water), Copper Tripeptide-1, Sodium Hyaluronate Crosspolymer, Pentylene Glycol, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin. 
  • ACTIVATOR: Aqua (Water), Glycerin, Dimethyl Isosorbide, Decapeptide-22, Oligopeptide-78, Palmitoyl Decapeptide-21, Zinc Palmitoyl Nonapeptide-14, Myristoyl Nonapeptide-3, Copper Lysinate/Prolinate, Methylglucoside Phosphate, Hydrolyzed Wheat Protein, Arginine, Pentylene Glycol, Xanthan Gum, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Ethoxydiglycol, Caprylyl Glycol, Glyceryl Caprylate, Phenylpropanol, Phenoxyethanol, Chlorphenesin.

With so many benefits and being a completely cruelty-free product, there is no reason to hold out on a product like this. A highly rated and reviewed product, you can rest assured that your skin will radiate like never before.  

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